Antinociceptive actions of intrathecal xylazine: interactions with spinal cord opioid pathways
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چکیده
منابع مشابه
Antinociceptive actions of intrathecal xylazine: interactions with spinal cord opioid pathways.
We have studied rats with chronically implanted subarachnoid catheters. Xylazine, an alpha 2 adrenoceptor agonist, was injected intrathecally and nociceptive thresholds measured at two skin sites: the tail and the neck. Intrathecal xylazine (dose range 24.3-389 nmol) produced increases in electrical thresholds for nociception in the tail without any change in the neck; this observation suggeste...
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INTRODUCTIONS: It is well understood that dopamine (DA) has an action in the brain as a neurotransmitter and neuromodulator. However, little is known about the roles of DA in the spinal cord. The periventricular, posterior region (A11) of the hypothalamus is the principle source of descending dopaminergic pathways. Focal electrical stimulation in the region of the A11 area suppresses the nocice...
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Mammalian zinc ectopeptidases play important roles in turning off neural and hormonal peptide signals at the cell surface, notably those processing sensory information. We report here the discovery of a previously uncharacterized physiological inhibitor of enkephalin-inactivating zinc ectopeptidases in humans, which we have named Opiorphin. It is a QRFSR peptide that inhibits two enkephalin-cat...
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The nonopioid actions of spinal dynorphin may promote aspects of abnormal pain after nerve injury. Mechanistic similarities have been suggested between opioid tolerance and neuropathic pain. Here, the hypothesis that spinal dynorphin might mediate effects of sustained spinal opioids was explored. Possible abnormal pain and spinal antinociceptive tolerance were evaluated after intrathecal admini...
متن کاملAntinociceptive role of 5-HT1A receptors in rat spinal cord.
BACKGROUND Intrathecal administration of 5-hydroxytryptamine (5-HT) is antinociceptive to noxious heat and electrical stimuli. The contributions of different receptor subtypes to the antinociceptive effects of 5-HT are controversial. The main reasons for this are the poor receptor subtype selectivity of some agonist drugs and the difficulty of restricting drug action to the spinal cord in some ...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1996
ISSN: 0007-0912
DOI: 10.1093/bja/76.4.544